I've a few whitetails IE around 25 or so. Probably close to 50 pigs. With handguns that is.
I've found that I've never lost a pig shot in the lungs with a 22 LR CCI Mini Mag HP round.
Deer have been shot with 357, 44 mag, 45 acp and 10mm. I never liked how they killed until the 10mm.
Hands down its rare to have a deer go more than 25-30 yards with a 180 XTP through them. So much that for on purpose hunting I have started to convert all handgun rounds to XTP.
That said bear/moose defense loads still get heavy hard cast bullets driven at a speed that I can control recoil for follow up shots.
Having used hard cast lead WFN type bullets along the way on deer a couple of times I simply didn't see anything the XTP didn't do better.
