.22 LR - great for small stuff and practice
6mm AI - about perfect for varmints too big/far away for a .22
.300 WSM - the .308 diameter currently has the best general purpose NA hunting bullet in the 200gr Terminal Ascent, the WSM is the best case for general hunting use
.375 WSM - the best setup for a bolt rifle either for big bears or where big bears might show up to a shot
.50-110/.50EX Nitro - Elephant-level power, levergun speed
.416 Rigby - best of the magnum Mauser cartridges for dangerous game
9mm - best concealed carry cartridge, also good in full sized 1911s
.44 Magnum - enough gun for big bear protection without excessive recoil (or excessive weight to avoid recoil)
12ga - best shell for large birds
20ga - best shell for small birds and mixed bag hunting