Trouble with magnum revolvers is loudness, especially indoors and without muffs. You can get permanent hearing damage from shooting one of those bad boys under those circumstances.
A LGS sells Glock barrels in 9mm and .45 that are threaded for the suppressors they sell. Quiet guns are easier to shoot well, due to the lower perceived recoil. Just a thought.
If you aren't wearing muffs indoors or out to shoot, then you WILL damage your hearing, whether .22 LR or .44 magnum.
(Ask me how I know)
You may not notice it now, but you will when you get older. Guaranteed.
But, a magnum revolver isn't any problem with hearing protection.
Also, with proper hearing protection every gun is a quiet gun.