Shot my first buffalo, a very big-bodied Botswana bull, 20 years ago with a 300-grain Combined Technology Fail Safe (very similar to a 300 TSX) from a Ruger No. 1 .375 H&H. It was one of two mature bulls trailing a herd of around 250, and my PH (the very experienced Russell Tarr) whispered to damn sure wait until the bulls separated, so there was no chance the bullet might hit both. I waited, and the FS (which was much like the TSX in construction) not only exited the bull, but left an exit hole the size of my fist.
If we'd been hunting in thicker "cover," it very well might have gone through and hit another buffalo. Which is exactly what happened when my friend Brian Pearce used solids from a .45-70 to kill a bull a couple years later. The bullet exited and hit an unseen cow behind the bull--luckily hitting the "right" place and killing the cow. Not all exits are so lucky.
