Funny how shot placement trumps.
I took my 375 as back up to my 404. PH wanted 300gr Barnes or A-frames in that one vs a 270gr TSX. Whichever one shot the best. 300gr Barnes TSX it was.
Did end up using the 375 on Impala, Sable, Hartebeest, Zebra and Roan. Worked just fine.
I think a 270gr TSX would work fantastic also and would have no issues using them on Buffalo. I have a good load all worked up for the 270's and they will become my go to bullet in the 375 once I finish shooting up the 300gr bullets.