jfo4- There's very little data available for the 416 Ruger. But there is for the 375 Ruger (same case, larger neck diameter). This may sound strange, but I'd start w/ 300gr. 375 Ruger data. The ~23% increased cross sectional area of you 0.416" bore will lower the pressure of the 375 Ruger data significantly. I'd use the starting load of 4895/Varget/Re15/H335 for the 375 version. Or adjust data for the 416 Remington down. Hodgdon does list the 300gr Barnes TSX for the Remington version. Lower these starting loads 10% (H4895 does well w/ reduced loads) and work up. The Buffalobore 416 Ruger 350gr TSX load has a velocity of 2550fps, while the 416 Remington 350TSX is 2625fps. Obviously the 300gr TSX would be capable of higher velocity than the 350gr. You have a chrono? But you'll have to discover that on your own it appears! -Mark&Belle