I've shot deer with 150 and 170 gr. core lokts, 150 and 170 gr. power points, 170 gr. silvertips, 150 gr. hornady interlocks and 170 gr. sierra fp.. They all killed deer very effectively. Years ago I killed a bunch with handloaded 150 gr. core lokts over a heavy charge of 3031 {actually an overload according to todays data}. A few of those at ranges between 200 and 250 yards and one at just over 300. All died quickly and none required a second shot. My current loads are pushing 170 gr. sierras at 2240 fps with cfe .223. They group 3 shots into 3/4" at 100 yards consistently and produced quarter sized wounds out the far side of the two deer I killed with them last season.