That's sort of "6 or a 1/2 dozen, which is better?" But I think I'd go with the 168 and I'd bet it would leave a good exit hole. I like both cartridges. Depending on game, if the expected yardage is long, Or the game was large or both I'd go with the 300 otherwise the 30-06.

I prefer classic.
Semper Fi
I used to run with the hare. Now I'm envious of the tortoise and I do my own stunts but rarely intentionally