It would be hard to beat H4895, I also like the 53gr Varmageddon
I used to think that too. Don't discount AR Comp though. It drops through the powder measure better and also produces very consistent accuracy and good velocities. Because of this, I can just drop a charge in and load the bullet. Much faster and more convenient for a "varmint" hunting rig, where you may be loading a bunch.. H380 also works well, but H4895 and AR Comp both edge out that powder for consistent results. As for "250 yard shots" with a 22-250. You got to be kidding me. Right?