The 55 gr Varmageddons shoot great in my Sako 22-250. My older boy has a factory Rem SPS (schitty plastic stock) that shoots way better than it should with these. Go to powder was H414 but you have to watch it in the summer heat if you are running near max loads. I once blew a coyote almost in half with this bullet in a 220 Swift. I’ve been meaning to try CFE223 in the 22-250 but haven’t had any time to.
Don’t over think this. Work up a load that shoots in your gun. They’re only coyotes; not cape buffalo. Nearly any 55 gr bullet outside a FMJ will end them. I killed lots of em with the 55 gr cup and core bullets of yore.
