Nothing than bigger than elk, but I have been loading 220 gr RN for a lot of years. They are Sierras though. I used 4831 and 58.5 gr for about 2500 fps, but that is a hot load. Most kills, bullet was found under the hide on far side after double lung shots. I shot at least 20 elk with them. Further shot was 347 yards that my Lieca 1200 RF showed ,according to my notes. Most kills were in the 50 yard range in heavy blow down timber. I can't say anything about bone breaking ability as I don't take those shots.
Someone posted quite awhile back that they used 200 gr Partitions, but I never saw a need for them at those velocities
