I built a DIY 308 last year and used it with success on three deer, building another one now in 6.5CM (ammo is easy to find and affordable, performance is fine and one of the only Proof pre-fit barrels available), just waiting on the McMillan stock which should be delivered in a week or so. I've got one more DIY pre-fit build in mind that I hope to get finished this year, that would be a 7mm PRC. Depends on where and when I can find a receiver that meets my needs (affordable and takes Proof pre-fits).
