Maybe a little bigger 9mm? My wife has gone through a glock 42, lcp, g19.

Her probably favorite to shoot is our m&p compact 22lr. If anything, that would be a great gun just for her to shoot, possibly even carry.

Once my wife shot my full size m&p 2.0 9mm, she had to have it. She carries it in her purse.

If you are contemplating a 22lr, I would look at the m&p compact.