I agree that mood of the buffalo at the shot can influence their reaction to the shot.
I also believe that buffalo in more controlled environments will also react differently than buffalo that have lions, poachers, etc. harassing them all the time.
Huge fan of the Barnes bullets and my one and only buffalo was with a 400gr out of a 404 Jeffery. Single shot, no muss, no fuss. Went less than 100 yards.
I now have a 416 Remington that is shooting 350gr TSX's very well.
