Agreed.
if it is a weatherby use 7828 first
Always try 7828 first. Shrap suggests a great bullet too. That's what I started out loading in my 300WBY's. 84 grains usually did the trick quite nicely. However lately, I've tried the 175 LRX with 7828 and they shoot damn well.
H4831 is also a great powder to consider.
As far as sizing die setting. It's just like any other cartridge. PFL sizing with your RCBS die will work just fine. The 300WBY is not that finicky.