I have used the .25-06, .270 and .30-06 cartridges for a considerable portion of my hunting. I have been completely satisfied with each of them.
Have fired a few .280’s in my time, but never hunted with one. I am certain that it would do for anything practically speaking that the others would do.
But, that being said, I would take a .30-06 over a .280 any day of the week.
