No difference at all out at 500 yards on most game, both have speed and bullet technology, especially because they are 7mm and 7.62mm. The 280 Rem and 30-06 are not separated by much however there are a couple of considerations. The 280 Rem is the easier button for long range capability having heavy for caliber projectiles at high velocity. The 30-06 has long range capability with numerous 7.62mm projectiles for any occasion. It also has more horsepower for tackling the heaviest of game in close. Being able to throw 220 grain loads at 2,400 fps and 250 grain loads at 2,300 fps.
It really just depends on what bases you are trying to cover. Most likely that will depend on where you live, what you intend to hunt, and how you intend to hunt.
You DUMB Fhuqks never cease to amaze,by simply doing your best. Hint.
Fhuqking LAUGHING!...............
