Jeff,
I would guess that even if they came apart on a close shot they would do plenty of damage so its not the close range performance you should question(of course you knew that)
So how would the 225 work at 350 yds? Well the next best thing to shooting 30 deer at that range is shooting wet paper at that range. If it were me I might try shooting a positive and negative control as well. A bullet that you expect to expand well and one that I suspect wouldn't like maybe the hornady 250g SP.
Have you played with MD's tac loads for the 200g hornady or the barnes 200 TSX? The added velocity MD demonstrated might help a bit with wind drift and drop. The 200g tsx seems particulary interesting but cost wise I might prefer the 200g hornady.
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