Here's another vote for the 280. I've had one for 10 years in a Ruger 77 Stainless Laminate. I love that gun and will never part with her. Seems a lot of guys also love their .280 around here. I've taken elk, deer and antelope with mine, it never left me wishing I had more gun. I've never seen such a consensus on a forum about anything, much a less a personal choice like cartridges. Get the .280 and live happily ever after.