I find it interesting that nearly all the posters are keying in on the chambering and ignoring the rifle. I'd pick a Win. model 70 over a Remington 700 any day, have had too many bad experience with Remington's lack of Quality Control. I would not choose a single shot as a primary hunting rifle, they are a lot of fun but somewhat limiting.
The .280 offers a theoretical advantage over the .308 for long range hunting but that matters on paper only, not in the field. I have and use both.