A 300 grain bullet in a 45-70 is a choice, but never the best choice
Oh, the JHP inside of 100 is just NASTY on whitetails.
But, for anything else... esp. when any "range" is considered, no, it ain't; regardless of whether you prescribe to MPBR, energy, momentum, drop... it just fails to carry the mail the way a heavier, higher BC slug can and does.
