I don't have a burning desire to change my 45.70s at all.
They have worked wonderfully well as is, but if you do, have fun and post a report of what you find.
The 300gr Partitions have been fine for 2 Cow Elk so far, but I'm typically hunting in the thick stuff at archery range. 405gr rem have been fine too.
Foot Pounds of Energy ? Yawn, get close and place your shot, use your F.P.E. to carry them out!