For the peanut gallery:
Here is part of a post from Dogzapper which may help:
Most folks believe that the .22-250 is simply a necked-down .250 Savage. This is not true. The .250's shoulder angle is 26 degrees, 30 minutes and the .22-250 has a shoulder angle of 28 degrees. Also, most sources agree that the dimension between the case head and the shoulder is roughly .003" more forward on the .22-250 (a result of the sharper shoulder, no doubt).
