With the 225 Sierra keep the speed up this is a tough bullet it is the most accurate bullet in my Rem 700. Cloverleafs with RE7 powder a little faster with Varget but still under MOA. All of the 200 grain 35 Remington type bullets thrive on RE7 as well. No experience with the 250NP But RE 15 or Varget should be all you need.
