I have a Ruger 77 in 250 savage made in the 70's that will not hit the barn in the same place,even when standing inside the barn.
With 87-100 grain bullets of various makers it would not repeat.
One day i loaded some 75 grains for another rifle and thought i would take it along,while not in the 2inch range it did repeat the shots.
Tried several powders as well.

It sets in my shop now waiting for me to shoot some 80grain lead cast in it again.

It did shoot the first real good.
I think along that time that had some crappy barrels.