I've used 180 Accubonds out of a 300 win and 270 and 300 grain TSX out of my 375H&H. I've shot springbok up to cape buffalo. In all cases bullets performed exactly as advertised.
I did shoot an eland with a 180 Accubond on my 1st plains game safari and although they worked the eland was not impressed and required several follow up Accubonds. I would have much preferred to have used either of the 375 TSX rounds on eland.
On my 2nd trip I used the 375 exclusively with 300 grain bullets. Worked fine on plains game, leopard, and cape buffalo.
Properly applied on game either bullet works extremely well. I think the key is to make sure that the caliber and bullet is adequate for the game you will be hunting.
I will agree that African game animals are seriously tough critters so my thoughts on caliber and bullet weights are bigger is better.
