Finally had the time to scroll through all the posts in this thread. Most of my big game hunting is behind me--it will virtually all be deer and elk from now on, unless lightning strikes and I draw a desert bighorn tag. Anyhow, FWIW, here is my big game arsenal now:

.257 AI for deer and pronghorns (If I ever decide to hunt pronghorns again).
.30-06 for most everything, depending on how I feel on a particular day.
.338-06 Improved, exclusively for elk hunting with an elegant custom rifle.

(Edited to add: I still have one custom build fermenting. If it comes to fruition, it might be my only big game rifle.)

Last edited by mudhen; 01/09/17.
Ben

Some days it takes most of the day for me to do practically nothing...