If this includes only NA big game hunting (not varmints or practice), then I'd go with two nearly-identical 30-06:
Main Win70 FWT with Brown/Bansner/Rimrock stock (pre64 or stainless Classic), Leupie 6x36 duplex
Backup Ruger MKII stainless with zytel stock, Leupie 4x
I would load Barnes 130TTSX for most things, Nosler 150 ETips for bigger things, and reserve the option to run Partition 180 for anything. And I would stock pre-sighted Leupie 4x in QD rings for both.
