Given criteria that this is for "big game" which means I can exclude small game, predators and varmints, my choice


Left handed 308 win (left handed 270Win or 30-06 will work just as well)

375 H&H if I could get one in left hand config.

last, a slug gun(12 or 20ga) for the states that don't allow high power center fire rifles to hunt big game, ie deer.