I have an '08 2500 with the Cummins. It also has a manual trans which is only available with the Cummins. It turned over 100k this fall.
The clutch went out at about 95k. I've since heard that that's normal for them. I put a heavier duty clutch in that's supposed to last the life of the pickup.
They're famous for the front ends to go bad at 75 to 100k, tie rod ends, damper, and ball joints. My tie rods went at about 95k. A friend with the same pickup needed a damper at about 90k.

“In a time of deceit telling the truth is a revolutionary act.”
― George Orwell

It's not over when you lose. It's over when you quit.