The 250-3000 is one of my two favorite cartridges, the 257 Roberts being the other. Have two rifles in the 250, a 1953 M99R, and a Ruger M77 Tang Safety. Both have killed a number of deer and coyotes, the Ruger has an antelope to it's credit as well.
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Last years buck, 150 yards with a 100 Interlock out of the Ruger. The bullet center punched the near shoulder, took the vessels off the top of heart, mashed the lungs and was found between the far ribs and the hide weighing in the low 60s. The buck went only 20-30 yards.
It was indeed enough!