Regarding the Ruger #1, from a practical POV, I can't think of a rifle less optimally suited for the 250-3000. Why chamber a single shot falling block rifle without COAL limitations for a short cartridge?
A #1A is a handy, compact rifle, yet still offers a 22" tube. It's not on my "buy" list yet, but lots of folks seem excited to get one. You can of course do anything you want with bullet weight or seating, as long as the round will chamber. Last, if one is inclined to load warmer than factory, it's better in a #1 than a fine old Savage.
