I'd have an awfully hard time narrowing my safe down to two deer rifles. Some have quite a bit of sentimental value, even though they seldom get used.
The two that most often get reached for are.
Remington Model 7 in 7mm-08 paired with a Leupold 2-7. That's what goes along with me more often than not. If the games a little heavier or the reach is expected to be a little longer than out comes my Ruger MKII 7mm mag with a Leupold 4.5-14.
Feel more than comfortable taking along one or the other for pretty much anything I'll ever get a chance to hunt in the lower 48.