Last Fall I shot 3 deer with a 180PT/300WSM, they all died.
Two weanlings at 100-150 yards, bullet opened, toasted the lungs and left a minimus exit, no carnage.
Shot a big bodied mule deer 3 times at 420 yards. He kept walking after the first shot but dropped at the third. One of the bullets didn't exit(quartering away) but it was dark and I didn't find it boning out the meat.
I also shot a coyote with that combo and it died also.