My two cents worth,
I have had both. I prefer the .45 colt.
The .45 is easier on the ears than the .44. An important feature when you leave the range and shoot something out it the sticks, where you will likely need it most.
In the same gun, like your Blackhawk, the .45 will be lighter to pack as there is less metal than the .44.
It can shoot bigger bullets out of it at like velocities and can be more powerful than the .44, in the right revolver.
I like the history of the cartridge and that it seens to have the right balance of shootability, penetration and wound channel for anything that I am likely to shoot with it. When you hit something with a big .45 cal bullet, things stop twitching very quickly. It just plain works.
Shot loads out of the .45 hold more pellets and are just plain nasty up close.
Having said all that, neither is a bad choice, they both will still be killing stuff well after we all are history.
