Given that you are gonna load for it I would (and did) get a 45 Colt.
Given you are gonna get a 45 Colt, I would (and did) get a Standard Blackhawk or BH Bisley, these can take the +P loads.
(Not one of the new med. Frame BHs)
My wood grips came from Hogue and they are nice�
But�.
Wish I had bought some fancier grips from here
http://www.clccustomgrips.com/Snake