Linebaugh says so and tested it thoroughly, but personally I'd limit it to bullets under 280 grains and load to 45 ACP pressure (21,000 CUP/PSI), ESPECIALLY an older one.
Speer lists loads listed up to 25,000 CUP; I'd definitely keep them under that.
The cylinder walls at the bolt notches are thin, even in an early 29. Later models like the Mountain Gun appear better designed; a lot better bolt, bolt notch and hand system, if you are firing a lot of rounds.
The difference between 1,300 fps and 950 from a 45 Colt with solids on deer sized stuff is less than marginal...
