I'm not real interested in getting into a pizzin' match about which N-frame came first, nor whether the M29 has a stronger frame than the M25.
http://www.handloads.com/articles/default.asp?id=12I stumbled across John Linebaugh's articles on his research with 45 Colt guns a long time ago, and that answered any questions I might have had. Like Linebaugh, I've taken to carrying a 4" Model 25 or 625 for most of my big-bore revolver carry and I'm satisfied it can handle all the power I need it to handle.
No one has deliberately blown up more guns than Linebaugh. If he says the M25 can handle the loads specified in his articles, I believe him.
BTW, TnC, I agree completely with your statement regarding moderate pressure loads in a DA revolver. Whether you're carrying a 45 Colt or a 44 Mag, a guy should be GTG with such a rig.