If this were for hunting all over North America, and money were no object, probably either a worked-over, stainless, New Haven Winchester 70 (probably go with a Brown stock) OR a Remington 700 Ti with a slightly heavier barrel contour in 7mm Rem mag, although a 30-06 would be fine too. If confined to more localized stuff (meaning not big bears, elk, or moose), probably the same in 7-08. If on a budget, probably just a stainless Remington 700 in 7-08 or .243.

I'd use Talley lightweights and a Leupold 6-18X40 with a standard or maybe heavy Duplex regardless of the rifle chosen.