I have used snake loads in 22,38,357,44mag and 45acp. The 44 capsules you load yourself are pretty effective on snakes. They're also damned good for old bulls that have decided never to leave the mesquite thickets. I guess you could put out an eye.I try to shoot them in the nose but with horse and bull moving who knows where I'm hitting. 2 or 3 hits have turned some rank turds around and they went right on to the corrals.
I have a 629 with a 3 inch barrel thats real handy horseback.
Fred
