Just loaded up some rounds last night for a new 280AI. Had some fire-formed brass. FL resized them and used Rel 22 with 162 Gr. A-Maxes. Expect to get around 2,800 FPS out of the 23" barrel (per quickload).
I did fill a case with H20 and weighed it just to make sure of capacity. Quickload had 74 grs water and I measured 72.5 grains. Easy fix.