battue,
Not really. I did have a couple of misfires with some Remington .22 Short ammo recently, but only in one of several rifles I tested it in, and both rounds fired the second time I tried them.
To be honest, until I became a member of the Campfire I hardly ever even thought about rimfire misfires, because I so rarely encountered them. I don't know why that would be, because my wife and own over 15 rimfire rifles and handguns, so there's certainly a wide range of firing pins and springs.