I use the Remington 405gr JSP launched at 1800fps from a Marlin Guide Gun. I took a Bull Elk at 18yds that was running at me. The bullet penetrated a total of 30", having busted through spine, expanding to .9", and coming to rest in the grass bag. One very dead Elk. I kindof doubt he'd have died any faster with a ScreamingDeathMagnum.

I don't use cast bullets because unless they are really soft they tend to be hole drillers.

Castor Oil Case Lube
Lee Auto Bench Prime