Only an experience of 1; but, have shot 1 whitetail with a 350 gr. Hornady jacketed RN at about 40 yards. It is the only deer I have shot that I saw the entrance hole as the deer stumbled away. The deeer fell to the shot, got up and leaped once , got up stumbled again after 1 leap and laid down dead about 50 yds. away. This from a Ruger #1, with a load of 4895 that did not exceed Springfield pressures. Had about an inch of rain overnight and could still backtrack the blood trail from where it laid to where I shot. I was impressed, but have used small fast calibers since; no failures, but no deer that could not have been taken with the 45/70. Maybe it's time to start using the 45/70 again.
