I took a lot of "long range" game in the 80's and 90's without turrets or ballistic reticles by simply knowing trajectories and the size of the critters I was hunting. There are a whole hat load of standard cartridges that with a 225 to 250-yard zero (~ 3" high at a hundred) are 5-8" low at three hundred, 16-20" down at four. They are then down about 33-36" at five hundred yards.

Long shots without contentious winds were on calm, broadside venison whose average size made hold-over very doable. While a little retro-, this still works.