I've been shooting the Hornady 300gr XTP (.452) for EVER..
If you dont mind the Sabot (and I dont) they are awesome.
They shoot 1.5 MOA in my T/C Encore 50cal.

I shoot them over 90 grains of loose 777 FFg. I have never had one stay inside a deer.

"Everything that lives and moves will be food for you. Just as I gave you the green plants, I now give you everything." Genesis 9:3