I've spent quality time with two 338-06's, two 35 Whelens, one 9.3x62, one 338 WM, one 375 H&H, and more 308's and 30-06's than I can count. Some of them hit harder (whatever that means) than others, but I think that if I need more than a 30-06, then I need a LOT more. That starts with the 375 and might actually be a 416. Frankly, I'm less concerned with terminal ballistics than I am with finding ammo if an airline loses mine for some reason. So If I were hunting North America, then I'd go 30-06, 338 WM, and 375 H&H in that order. If I were headed to Africa, then I'd still make sure that I had a good 30-06, then I'd get a Model 70 or CZ 550 in 375 H&H because they're cheaper than properly converting an 1917 Enfield.
Okie John
