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With bullets up to and including 220gn I favor SR4756 for light to medium loads (CFE Pistol now that 4756 is no longer made) and 2400 for heavy loads. It seemed to me that H110 gave a lot more muzzle blast but no better performance than 2400. I was not impressed with AA9. Liked Blue Dot but lot-to-lot variation was extreme and it is no longer recommended by Alliant.

With 250 and 265 gn WFNGC H110 is very good and Lil’ Gun even better giving higher velocity and tighter groups. 300MP is a viable substitute for H110 and somewhat cleaner burning. 2400 gave great accuracy with 265 gn at 1150 fps. CFE Pistol gives great accuracy in my 5.5” Redhawk with 265 gn at just around 1050 fps but is only mediocre in the Model 57.

I strongly recommend you buy just one brand of brass and stick with it. In my S&W I can use up to 18.0 gn of 2400 with Lyman #410459 in Remington cases without sticky extraction (all six cases ejected without resistance). With Winchester cases more than 16.2 gn will cause sticky extraction.

I use Federal 150 primers for all loads and have seen no advantage with magnum primers.

Cheers