I can't say from actual experience because the only cartridges I have used in Africa were 404 Jeffery, and 7.62 NATO. I saw the 458 Winchester used a number of times with excellent results.
But I have a LOT of experience with the 375 in other places, and the 300 Gr Nosler Part. has been one of the best, if not THE best bullet I have ever used on everything I have shot with it. Elk, Moose, the bears I have killed, and various domestic cattle and horses are not as big or tough as cape buffalo, so if someone with actual experience were to tell me that the 300 Gr Noslet Partition was lacking on Cape Buffalo I would have to believe him, (especially if they had experience on several instead of just 1-2) but for anything I have hunted, they have been as close to perfect as a bullet could be. I love them.
