I haven't shot the 300gr NP at a Cape Buffalo, but (out of a .375 Wby) it instantly killed the attached immediately and went through about 3 feet of bear and exited. The bear jumped when hit, spun around and tried to bite what it thought was biting him, and died 25 feet from where the initial claw marks and blood spatter were. I know that Cape Buffalo can be harder to kill, but I was pretty amazed by the performance.
